Let’s do something
about Chronic Migraine.

We are studying an investigational drug for
migraine prevention in adults • No cost to participate

The PREVENTION Study for Chronic Migraine - Now Enrolling


Just about everyone gets headaches. But a migraine is not just a bad headache. It’s an extremely incapacitating collection of symptoms, and can include:

  • Severe throbbing or pulsating sensation, usually on one side of the head
  • Nausea or vomiting
  • Extreme sensitivity to light and sound
  • Blurred vision

Migraine is quite common, affecting about 12% of the US population. And although there is currently no cure for Chronic Migraine, doctors and researchers are studying new preventative treatments that may help improve quality of life.

A new clinical study, called the PREVENTION Study, is being at conducted at approximately 25 locations across the US. This research study is to test an investigational drug for migraine prevention in adults when taken daily for 12 weeks.

Participants in the PREVENTION Study will receive all study-related care at no cost. They will also be compensated for their time and travel to attend periodic visits at the local study doctor’s office to monitor their progress (up to 6 visits over a 5 month period).

Frequent Questions


Clinical studies or trials are used to learn about the safety and effectiveness of new medications, medical devices, medical procedures, or other types of intervention. Although there are many types of clinical trials, all must conform to strict rules set by the U.S. Food and Drug Administration (FDA). These rules help protect the rights and safety of those who volunteer to take part in clinical trials.

It is expected that 300 people will participate in the PREVENTION Study at approximately 25 locations across the U.S.
The active ingredient in TNX-1900 has been used in previous clinical studies for chronic migraine and is currently used in other non-migraine medications that have been approved by the FDA. The PREVENTION Study is a Phase II study.
Now - the study is actively enrolling new participants on a rolling basis.
You will be compensated for your time and travel expenses related to study visits.

If you qualify and choose to join the PREVENTION Study, you will receive study-related care at no cost to you. This includes the study drug, as well as any visits to your study doctor’s office. Health insurance is not required to participate.

If you join the study, your participation will last about 5 months. During this time, you will be asked to meet with your local study doctor up to 6 times to provide feedback about your experiences. You will be compensated for your time and travel to attend these visits.
As with all clinical studies, your participation is completely voluntary. You may leave the study at any time without any effect on your future medical care.
To see if you might qualify for the PREVENTION Study, and to get connected with your local study center, the next step is taking the pre-screening questionnaire. Please scroll down to get started.

See If You Qualify


If you suffer from Chronic Migraines and are 18 - 65 years old, you may be eligible to participate in the PREVENTION Study. To see if you might qualify, and to connect with a local study center to learn more, please take the questionnaire below.